Treatment of rats with the nonspecific muscarinic receptor antagonist atropine or with the M1 selective antagonist pirenzipine, but not treatment with M2 or M3-selective antagonists blunts lipid-induced GLP-1 secretion [319,335]
As a result, your pancreas makes more insulin to try to overcome your increasing blood glucose levels
Similarly, ICV pretreatment or peripheral post-treatment with the DEETGE-Cal-Tat peptide was also able to decrease Keap1-Nrf2 interaction in the rat hippocampal CA1 region after global cerebral ischemia (GCI) and, as a consequence, to induce Nrf2 target genes and a powerful neuroprotection of hippocampal-dependent cognitive function after GCI [302]
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