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Reducing lactate production lowers H3K18la and suppresses tumor growth, while mechanistic work identified EP300-dependent H3K18la at the YTHDF2 promoter, increasing YTHDF2 and promoting decay of tumor-suppressive PER1 and TP53 transcripts, thereby facilitating malignancy [205]

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However, the IGF-I gene expression decreased with increasing severity of MASLD, suggesting that reductions of hepatic IGF-I production in patients with MASLD may be related to the severity of the damaged hepatocytes