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The cellular studies using CHO cells indicated that the pre-treatment of DSePA significantly upregulated the mRNA expressions of seleno-GPxs ( GPx1 , GPx2 , GPx3 , and GPx4 ), increased total GPx activity, and concurrently improved the viability of irradiated cells with a dose modification factor of 1.53 [85]

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In addition to the high discordance rates between monozygotic twins, the importance of epigenetic mechanisms is evident in the chronic relapsing nature of these diseases, and the higher incidence of MDD in women after puberty [15, 16]

Lynch, G

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