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HIF-regulated genes include plasminogen activator inhibitor-1 (PAI-1), cell death proteins such as BNIP3 and Nix, which can all contribute to the liver injury 35

In this process, ROS production by the RBOHs, RBOHD and RBOHF, is triggered in the cells that are directly subjected to stress, resulting in a state of activated ROS production

The incubation of solutions of GSH without the metal complex did not show any conversion to GSSG (Supplementary Fig

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casei, was also studied for its potential benefits in RA