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Advances in Gerontology, 01 Jan 2008, Volume 21 (Issue 3), Pages 372-381

In contrast, the proteasomes chymotrypsin-like (CT-L) activity varied with age and showed a significant decline only in later life, consistent with observations of 20S proteasome fluctuations during aging reported by ref

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Toxic overload does not explain every case of depression, but oxidative stress, inflammation, mitochondrial dysfunction, medication sensitivity and impaired methylation may contribute to depressive symptoms in selected patients

doi: 10.1016/j.ijdevneu.2010.01.002

2001;114(Pt13):236373