However, it is important to note that although the data so far is promising, the success of CT-388 in the T2D market will depend on continued positive results from ongoing and subsequent clinical trials (such as Phase 2 and 3 trials)
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Citation on PubMed El-Hattab AW, Li FY, Shen J, Powell BR, Bawle EV, Adams DJ, Wahl E, Kobori JA, Graham B, Scaglia F, Wong LJ
Within the TCA cycle, succinate is converted into fumarate by the succinate dehydrogenase (SDH) which represents the respiratory ETC complex II (CII) 73 (Supplementary Fig
10.1074/jbc.275.7.4613 96 LyapinaS.CopeG.ShevchenkoA.SerinoG.TsugeT.ZhouC.et al (2001)
A study showed that CR results in a reduction of insulin levels, thereby diminishing tumor PI3K signaling