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While the mid-regions of both peptides interact with the top of TM1/ECD stalk, the ECD, ECL1 and the top of TM2, exendin-4 exhibits more persistent interactions in the simulations, particularly with the TM1/stalk and ECD (Supplementary Tables 1 and 3)

Fibromyalgia, a chronic pain condition affecting 24% of the UK population, is characterised by widespread musculoskeletal pain, fatigue, and sleep disturbances

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