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Low iron is one of the most common reasons for deferral

doi: 10.1016/j.jid.2017.05.030 43 SwopeVBSauderDNMcKenzieRCSramkoskiRMKrugKABabcockGFet al

In conclusion, the occurrence of DFU is closely related to cell dysfunction, low-grade inflammation, and tissue hypoxia induced by hyperglycemia

The aim is to find the lowest effective dose

In consideration of the multiple metabolic and cardiovascular effects seen in subjects treated with GLP-1RAs and SGLT-2is (e.g., reduction of hyperglycemia, weight loss, free/fat mass and bone remodeling, anti-atherosclerosis, natriuresis), it is reasonable to speculate that GH and IGF-1 may play a about a relevant role in this context

Some patients are still getting them, though, and some compounding pharmacies are tweaking them enough (they hope) to bypass the FDA ruling