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After matching, the study included 162,253 case and control patients

Cells were washed twice with PBS, trypsinized, and then incubated with 500 l HBSS (C14175500BT, Gibco, United States) supplemented with 2 M C11-BODIPY 581/591 (D3861, Thermo Fisher, United States) at 37C for 15 min

The anecdotal reports and animal studies make these peptides seem like a miracle cure, but there are no large-scale human clinical trials or reputable data to support that claim

Alcoholic fatty liver disease is another major cause of fatty liver disease, for which carnitine supplementation may also be beneficial for improvement (77)

While topical application has minimal systemic absorption, the precautionary principle suggests avoiding use during pregnancy unless a healthcare provider approves

Conclusions There are presently no approved pharmacologic agents for the treatment of NAFLD and NASH, but numerous agents are currently being investigated in phase II and III clinical trials