semaglutide effects on kidneys Frontiers Long-term kidney outcomes of semaglutide

After NEJM published Olson-Kennedys paper, it received several letters to the editor pointing out its methodological problems, misleading conclusions, and inappropriate response to the suicides

Immunostaining was performed by immunohistochemistry (IHC)

Moderation matters more than usual

Statin therapy has proven benefits in reducing LDL cholesterol and preventing cardiovascular events in individuals with diabetes and ASCVD

The human results were real but modest

The resulting peptide has a nearly identical 3D spatial arrangement of functional groups as the originalmaintaining target binding affinitybut is unrecognizable to proteases that cleave L-amino acid peptide bonds