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Semaglutide can roil the stomach, causing nasty issues like nausea, diarrhea and vomiting

In individuals with overweight or obesity and type 2 diabetes, semaglutide 2.4 mg resulted in a mean weight loss of 9.6% compared to 3.4% with placebo in 68 weeks

The most frequently reported digestive complaints include nausea (affecting approximately 15-44% of patients depending on dose and indication), vomiting, diarrhea, abdominal pain, and constipation

But the injectable has some additional benefits

Symptoms are usually mild and temporary

Use oral rehydration solutions, stick to bland, small meals until stools normalize, and avoid taking anti-diarrheal agents as a long-term fix without medical advice