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To assess whether pharmacological inhibition of Ire1 can also alleviate IRI, we treated wild-type C57BL6 mice with vehicle, 48c, or liproxstatin-1 (a ferroptosis inhibitor used as a positive control for reducing IRI Ref

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Previous studies have demonstrated that deletion of HO-1 promoted ferroptosis in renal epithelial cells, suggesting its renoprotective effects in experimental models of kidney diseases [109]

verified by -radiation mouse model that resveratrol suppressed oxidative stress induced by ionizing radiation by activating SIRT-1 and others, alleviating radiation pelvic inflammation 41