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Alpha 2 Macroglobulin (2M) inhibits all 4 classes of proteases, including the enzymes that breakdown joint cartilage
A study published in the journal Expert Opinion on Drug Safety found that patients taking compounded GLP-1s were hospitalized over two times more often than patients taking FDA-approved versions
Emerging evidence also highlights the importance of dietary modifications to mitigate these risks
O.DallawayA.DuncanM.et al (2024)
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Medication Adherence While medication adherence factors into outcomes associated with most all drugs, it is especially important with GLP1 receptor agonists, as significant weight gain frequently occurs after discontinuation of the drug
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