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In addition, Daubry and colleagues demonstrated anxiogenic and inflammatory effects with 200 mg.kg -1 of caffeine in sleep-deprivation rats [37]

J Nat Prod 73(4):623627 Li YJ, Xuan HZ, Shou QY, Zhan ZG, Lu X, Hu FL (2012) Therapeutic effects of propolis essential oil on anxiety of restraint-stressed mice

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Moreover, the therapeutic efficacy of cancer treatments is often limited by systemic toxicity of drugs (6567), low efficiency in targeted delivery (6872), and physical barriers presented by solid tumors (7378)

Therapeutic approach of kras mutant tumours by the combination of pharmacologic ascorbate and chloroquine