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J.et al (2011)

Yang, N., Lejon, T

It nourishes nerve cells and promotes healthy brain metabolism, making it beneficial for both young professionals and older adults

Pregnancy NAC can cross the placenta, 131 but research into the safety of oral NAC during pregnancy is limited

Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

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