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the possibility exists that dual incretin receptor agonists work mainly by potent activation of the GLP-1R

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The semaglutide vs tirzepatide side effect comparison reveals that tirzepatide users may experience slightly different GI symptom profiles, with tirzepatide diarrhea being somewhat more common in clinical trials

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Continued treatment sustains results, with weight regain occurring gradually if semaglutide is discontinued without lifestyle maintenance