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The establishment, maintenance and characterization of midbrain organoids from human floor plate neuronal progenitor cells derived from a healthy (ID number: #232) and a Parkinsons disease patient with triplication in the SNCA gene (ID number: #317) were previously described by Muwanigwa et al

Taken together, these findings demonstrate that the 10 mg/kg morphine model recapitulates the known effects of opioids in humans, inducing constipation through inhibition of both intestinal transit and motility

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Clinical and biochemical results

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