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Fitchett D, Butler J, van de Borne P, Zinman B, Lachin JM, Wanner C, Woerle HJ, Hantel S, George JT, Johansen OE, Inzucchi SE

After propensity score matching the GLP-1 cohort (n=45,704) included 35,753 (78.2%) women and 7,852 (17.2%) men with a mean age of 61.1, while the OWLD cohort (n=45,704) included 35,732 (78.2%) women and 7,815 (17.1%) men with a mean age of 61.0

Originally developed to treat diabetes, semaglutide began making headlines in Hollywood for its remarkable weight loss benefits

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Furthermore, metabolic pathway alterations induced by GLP-1RA were significant only in obese mice but not in normal-weight mice