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These diverse biological activities have made GHK-Cu a focal point of research and development in dermatology, cosmetic formulation, and regenerative medicine, where its potential for anti-aging applications and holistic tissue health enhancement is actively explored

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Combination methods, such as homogenization-ultrasound-assisted extraction (HUAE) and ultrasound-homogenization-assisted extraction (UHAE), synergistically improve extraction efficiency by maximizing polyphenol release while minimizing oxidation (Yang et al., 2021a, b)