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Biol Chem 2009;390:191214 8

Glutathione is a key antioxidant in the brain, as it is the first line of defence in protecting against reactive oxygen species, which are cellular by-products that can lead to cellular damage, oxidative stress, and DNA damage

The 28-day (4-week) stability window is the limiting factor

The interplay between vitamin D and glutathione suggests that together they may offer a range of benefits, from improved immune function to better detoxification and chronic disease prevention

A key point of our study is our finding of a reduction of glutathione in NTG patients, suggesting that excessive oxidative stress may contribute to optic nerve damage and RGC loss independently of high IOP in glaucoma

Malenka RC, Nicoll RA (1993)