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Axelrod J (September 1948)

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The current medical consensus, reflected in obesity medicine guidelines from organizations such as the American Gastroenterological Association and Obesity Medicine Association, treats obesity as a chronic disease requiring long-term pharmacological management in most cases, similar to hypertension or hyperlipidemia

Eisner BH, Goldfarb DS, Pareek G

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From there, it goes straight to the liver via the portal vein for whats called "first-pass metabolism." The liver is the body's detoxification center, and it's ruthless with foreign compounds, often breaking them down before they ever reach the rest of the body