Some studies have shown reduced expression of major components of the electron transport chain in the striatum, frontal cortex, and substantia nigra of PD patients (43)
As of March 2026, though, Hers claims it will focus on offering FDA-approved weight-loss treatments
While there has been no clear association with certain psychiatric side effects, such as depression or suicidal ideation in research-based 31 or real-world 32 samples, the potential modulation of reward pathways by these drugs necessitates vigilant monitoring in patients with psychiatric histories, particularly in the setting of treatment with a medication that can substantially modulate the response of appetitive neurocircuitry to natural rewards such as food and water
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However, these investigations predominantly focused on their individual impacts rather than their combined efficacy