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Targeted deletions of Clock or Bmal1 genes significantly impact the rate of ageing by disrupting the circadian system, resulting in increased brain inflammation and neurodegeneration (Dubrovsky et al

It is in Phase 3 clinical trials under Eli Lilly's TRIUMPH program

However, in the long-term, this gene deficiency leads to inflammatory injury, fibrosis, and ultimately liver cancer at later times [152]

Sci Rep (2026)

October 5, 2023 by Bloomberg This photograph taken on February 23, 2023, in Paris, shows the anti-diabetic medication "Ozempic" (semaglutide) made by Danish pharmaceutical company "Novo Nordisk"

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