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Our choice of an active-comparator design was intended to reduce confounding by indication, severity of diabetes mellitus and unmeasured clinical characteristics, as basal insulin is used in similar clinical settings and stages of type 2 diabetes as GLP-1RAs [16]

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In addition, PCOS is commonly associated with metabolic disorders, such as obesity, insulin resistance, type-2 diabetes (T2D), dyslipidemia, and cardiovascular dysfunction 5,6

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