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Exploratory analyses from the STEP 1, 2, and 3 trials found that semaglutide 2.4 mg led to meaningful reductions in CRP a key marker of systemic inflammation and that those reductions tracked closely with weight and waist circumference changes

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Both BMAC and MFAT deliver similar results, although BMAC is generally used for younger, bone-involved OA, while MFAT is considered a better fit for elderly patients and those with higher body weight