This SC layer forms the principal barrier to drug permeation, largely due to its unique lipid composition, predominantly ceramides, cholesterol, fatty acids, and cholesteryl sulfate, arranged in bilayer structures within intercellular spaces [48, 223,224,225]
Hereditary angioedema: Estrogen-containing hormone therapy can unmask or worsen attacks, while progesterone-only or non-hormonal options are typically better tolerated
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Similarly, Mazahery et al
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