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The underlying pathogenesis seems to be related to an inflammatory response to foreign microcapsules due to a potential deficiency of enzymes needed to break down the poly-(d,l-lactide- co -glycolide) material into lactic and glycolic acid [58,59,60]

Lopez Current Medicinal Chemistry.2019

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The most discussed effects are sexual in nature: a subset of users report reduced libido, erectile dysfunction, and ejaculatory changes in approximately two to four percent of users in clinical trials, though real-world reporting and patient advocacy groups suggest this number may undercount persistent cases [6]

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