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This multifactorial approach resulted in the manifestation of typical clinical HFpEF features, including ventricular hypertrophy, increased collagen deposition and fibrosis, elevated blood pressure, and diastolic dysfunction

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To assess the acute effect of GQD on glucose tolerance, HFD-fed mice (35 3 g) were fasted overnight and administered GQD_H, GQD_M, GQD_L, or sterile water by oral gavage