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Pregnant and breastfeeding women should consult with their healthcare provider before using kojic acid products, as there's limited research on safety during these periods

Proliferating neuronal progenitors in the postnatal hippocampus transiently express the proneural gene Ngn2

Complete pharmacokinetic studies and long-term evaluations are rare

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This observation suggests that NAC may be beneficial in patients with non-severe neurologic dysfunction and that it should be administered at the earliest time possible before severe encephalopathy develops

The Hsieh et al