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People on the highest dose of orforglipron lost on average around 10% of their baseline body weight, for instance, compared to the 2.5% average weight loss seen in those taking a placebo

Trial discontinuation rates due to adverse events were modest (approximately 10-15% in higher dose groups)

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By activating these receptors, tirzepatide can help lower blood sugar levels, improve insulin sensitivity, and aid in weight loss by reducing appetite and promoting satiety