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Nevertheless, the development of an efficient GPx mimic for countering radiation toxicity may also face challenges like non-targeted radioprotection in cancerous cells, poor bioavailability, and poor metabolic stability [39]

The liver relies on glutathione for several essential processes that directly impact fatty liver progression

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Furthemore, an increased serotonin metabolism was demonstrated by diminished hypothalamic serotonin levels, lowered 5-hydroxytryptamine (5-HT)/tryptophan ratios and elevated 5-hydroxyindoleacetic acid/5-HT ratios, indicating dysregulated serotonergic system (Jia et al., 2024)

Previous studies have shown that a small molecule called Ras Lethal 3 ((1S,3R)-RSL3,(RSL3)) can pharmacologically inhibit GPX4 in skin and soft tissue cancer models in vitro and leads to induction of ferroptosis 10,11

& McCarty, M