In vitro studies showed that DHEA and DHEA-S accelerated dermal fibroblast migration (Stevenson et al., 2009) and prevented keratinocyte apoptosis via membrane binding sites (Pomari et al., 2015)
RAW 264.7 cells were cultured in complete Dulbeccos modified Eagle medium (DMEM, Gibco) supplemented with 10% (v/v) heat-inactivated fetal bovine serum (FBS) (Avantor Seradigm), 2 mM L-glutamine (Gibco), 1 non-essential amino acids solution (Gibco) and 1 mM sodium pyruvate (Gibco) below 18 passages without exceeding 90% confluency
Other companies and academic institutions are also investigating patch technology that could deliver metabolic medications in a controlled-release format
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Interestingly, this is not suppressed by oral glucose intake but responds readily to intravenous glucose