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Apart from lipid biosynthesis, another critical pro-inflammatory process that NADPH supports in myeloid cells is the production of cytotoxic, diffusive reactive radicals, such as reactive oxygen species (ROS) via NADPH oxidases (NOXes), as well as nitric oxide ( NO) via nitric oxide synthases (NOSes)

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33,34 Antineoplastic effects of ascorbic acid may also be related to its inhibition of the formation of certain carcinogens such as N-nitroso compounds