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The anti-inflammatory activity of melatonin may also involve Sirtuin-1 induction, suppression of NF-B activation, and stimulation of Nrf2 662

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These studies should explicitly address whether -3 PUFAs offer disease-modifying effects by incorporating advanced imaging biomarkers of cartilage integrity

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Biliary epithelium is well differentiated, forming more normal appearing ducts, with minimal glandular dilation in some cases

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