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Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise

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The risk of deficiency increases after age 75

The body has a ceiling for growth hormone response, and exceeding optimal doses may increase side effects without additional benefits