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Using BiLockCatcher, a genetic fusion of wild-type SpyCatcher and SpyLock, and SpyTagged antibody fragments, we generate bispecific antibodies in a single, scalable format, facilitating the screening of a large number of antibody combinations

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By the islet-like stage, there was a complete absence of islet hormone-expressing cells, and the authors showed persistent upregulation of endocrine precursor markers SOX9 and NGN3, which was accompanied by increased apoptosis

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