A reduction of 1.6% in A1C levels, the measurement of average blood glucose over the course of three months, is significant for people with Type 2 diabetes, who tend to have higher blood sugar levels and need to manage those levels to avoid secondary problems, such as heart disease, kidney disease or vision loss, according to the Centers for Disease Control and Prevention
Most experts recommend caution or choosing alternatives
The outcome represents a win for Health Secretary Robert F Kennedy Jr., who has publicly supported peptide therapies, and the broader wellness and longevity industry, which stands to profit substantially
Novo Nordisk has also cited indirect comparison data suggesting that fewer patients discontinued oral semaglutide due to side effects compared with orforglipron, though the companies and independent commentators note the significant methodological limitations of such comparisons in the absence of a head-to-head obesity trial
Kristin Baier, Calibrate's vice president of clinical development, in an interview
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