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Case Description/ Methods: A 37-year-old woman with obesity on semaglutide presented with two days of intractable left-sided abdominal pain, constipation, nausea, and vomiting

Side effects peak here, usually 2448 hours after each injection

It disrupts health across multiple systemsincluding the gut, liver, brain, nervous system, immune function, and sleep regulation

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Potential clinical applications of the angiogenesisinflammation hypothesis The AngiogenesisInflammation Hypothesis does not account for all clinical findings in DR

The peptide altered 127 genes in these cells, upregulating repair genes while downregulating inflammatory pathways responsible for tissue destruction