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Regarding the mechanism of action, is the GLP-1RA reducing lymphedema because of the induced weight loss or is there another mechanism at play

Study highlights Oxidative stress in sickle erythrocytes due to polymerization and auto-oxidation of HbS causes hemolysis and contributes to sickle cell pathophysiology

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However, patients should contact their healthcare provider if myalgia is severe, persists beyond 23 weeks, is accompanied by swelling or redness, or is accompanied by signs of serious muscle injury (significant weakness, dark urine, or fever)

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Medical guidance if you have cardiovascular disease, uncontrolled hypertension, kidney disease, or are pregnant