[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Berry SJ, Coffey DS, Walsh PC, Ewing LL
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Five PK studies all reported that children under 12 years of age metabolise paracetamol predominately by sulphation compared with adults ( n = 114 children in total) and that the adult pattern of metabolism is present beyond the age of 12 [44,45,46,47,48]
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J Neuroinflamm 15 Gerenu G, Martisova E, Ferrero H, Carracedo M, Rantamki T, Ramirez MJ, Gil-Bea FJ (2017) Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimers neuropathology and cognitive deficits
For example, in a mouse model of mucopolysaccharidosis (MPS VII), transgene delivery of b-glucuronidase in neonatal mice using an AAV2 vector resulted in the mice developing hepatocellular carcinoma (HCC)with evidence of AAV integration within the tumors [149, 150]
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