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Int J Mol Sci 2022;23:9309

Besides, in the NF-B signaling pathway, the phosphorylation of MAPK could lead AP-1 together with JNK and p38 to translocate into the nucleus and result in the upregulation of the proinflammatory cytokines ( Damage-associated molecular pattern (DAMP), such as UA, is produced or released by damaged or dying cells