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Szafraski, S

The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549

Although report volumes differed markedly among drugs, which may introduce reporting bias, these data suggest that AEs associated with ICIs are frequently clinically serious and merit careful attention

Despite these challenges, pursuing further investigation into antioxidant enzymes, specifically superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase 1 (GPX1), as well as inflammatory markers such as interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-), remains crucial

Its impact on circulation and cellular signaling allows a broader control of inflammation