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Exendin-4, liraglutide and semaglutide can directly or indirectly stimulate POMC neurons in the ARC, while indirectly inhibiting NPY/AgRP neurons via presynaptic GABAergic neurons [82-84]

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- [Best Practices for Subcutaneous Peptide Injection]( *Journal of Clinical Pharmacy and Therapeutics*, 2022

Lifestyle-Only Approach: A structured plan focusing on nutrition, activity, and behaviour can still support steady weight loss without medication

Preventive Services Task Force (USPSTF) recommends screening for osteoporosis in women aged 65 years and older and in younger women whose fracture risk is equal to or greater than that of a 65-year-old white woman with no additional risk factors