Since the initial investigations began in the 1960s, scientists have explored its possible roles in sleep regulation, stress adaptation, pain modulation, and neuroendocrine function
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A WHO consultation identified the most vulnerable groups as elderly individuals, infants, preschool-aged children, and pregnant or lactating women, due to either increased nutritional demands or impaired absorption capacity ( Addressing the prevention of B12 deficiency and its public health implications requires a comprehensive, life-course approach based on integrated strategies targeting early detection, dietary optimisation, and effective supplementation, in order to mitigate the long-term consequences of inadequate cobalamin status (Organization, 2000)
It is also banned by the World Anti-Doping Agency (WADA).
Clinical trials demonstrate efficacy and safety under controlled conditions