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2013;8(2) doi: 10.1371/journal.pone.0054016

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Characteristics of selected studies Participants The studies involved patients diagnosed with PD, with ages ranging from 18 to 84 years

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Zhang and colleagues showed that the catalytic activity of JmjC domain-containing histone demethylase 1 (JHDM1) is halted when ascorbate is withdrawn from the in vitro assay, most likely due to the reduced content of catalytically active Fe 2+ (reviewed in ref