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[5]Mittra PK, Roy SK, et al

Oxidative stress and heart disease are connected through several biological pathways, including endothelial dysfunction, inflammation, lipid oxidation, and mitochondrial injury

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Ferric ion(Fe) binds to transferrin, is internalized via TfR-mediated endocytosis, reduced to Ferrous ion (Fe) by Six-Transmembrane Epithelial Antigen of the Prostate 3 (STEAP3), and released into the cytoplasm by divalent metal transporter 1 (DMT1) for mitochondrial use

Ghezzi, 2011

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