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A caveat of using these medications is that many have reduced renal clearance due to declining kidney function or are contraindicated and often require careful dose adjustments [11,12,13]

And expect advantages beyond increased GLP-1 levels

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Supporting hydration, normal kidney filtration and adequate bicarbonate buffering may help create a more favorable environment for the removal and metabolism of adenosine, homocysteine and other metabolic by-products

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