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Following secretion, PYY is rapidly cleaved by dipeptidyl peptidase-4 (DPP-4) to its active form (PYY 3-36) acting on neuropeptide Y receptor type 2 (Y2R)

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Individualized dosing, regular laboratory monitoring (particularly IGF-1 levels), and physician oversight are key to maintaining safety and optimizing therapeutic benefit

Elevated homocysteine with weight loss

Once the autoimmune attack begins, the process is often irreversible, underscoring the challenge of effectively preventing and treating T1D