Sc profiling of endometrial organoids [1, 16, 62] revealed that in culture conditions without hormones, most cells are in a proliferative state ( TOP2A , PCNA ) and express ESR1 , indicating their existing responsiveness to E2 (Fig
doi: 10.1126/scitranslmed.3007218
The increase in testosterone can promote the development of secondary sexual characteristics and, in conjunction with follicle-stimulating hormone (FSH), support spermatogenesis
Additionally, in the adipose tissues of animals treated with AOD 9604, increased lipolytic activity was noted
Combined sample size is roughly 30 patients
Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection ( 4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges