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In the SURMOUNT-1 clinical trial, participants on the highest dose achieved 22.5% body weight reduction over 72 weeks

Other common effects include fatigue, headaches (6-14% incidence), dizziness, and injection site reactions for injectable formulations

Pros: Modest weight loss (typically 5-10% of body weight) Can be used long-term Available without prescription in lower doses Cons: Gastrointestinal side effects Requires strict low-fat diet adherence May interfere with absorption of fat-soluble vitamins Phentermine (Adipex-P, Lomaira) Phentermine is an appetite suppressant that affects the central nervous system

3 Melatonin regulates mitochondrial homeostasis 3.1 The function of melatonin in mitochondrial biogenesis Melatonin can regulate mitochondrial biogenesis by influencing metabolism and the redox state (Figure 2)